Host Cell Proteins
Identify, Assess, and Quantify HCPs with our Advanced LC-MS Solutions
Host cell proteins (HCPs) are critical impurities in biologic drug products that can compromise product stability, pose safety risks, and lead to adverse events for patients. Our mass spectrometry (MS)-based HCP detection solutions align with the latest USP guidelines, offering unparalleled sensitivity and specificity to ensure the integrity of your biologics development pipeline.
Detection and Analysis
Why Choose LC-MS for HCP Analysis?
- Unmatched Sensitivity and Specificity
LC-MS directly detects proteins, including low-abundance HCPs often missed by traditional methods such as ELISA or Western blotting.
- Comprehensive Proteome Coverage
Analyze the entire proteome in one injection, identifying both known and unknown HCPs, even those with atypical characteristics.
- Quantitative and Qualitative Insights
Perform detailed profiling of HCPs, gaining actionable insights to optimize purification and de-risk drug development.
- Cost-Effective and Efficient
LC-MS eliminates the need for costly and time-consuming custom ELISA development, providing rapid results throughout the biologics manufacturing process.
How we Work
Our Solutions for HCP Detection
- Sample Preparation
Prepare samples collected at various stages of development for a comprehensive view of HCP contamination.
- Advanced LC-MS Analysis
Identify and quantify HCPs with precision, leveraging robust databases of expression systems and optimized methods.
- In-Depth Data Analysis
Our bioinformaticians deliver detailed reports, flagging problematic HCPs to guide your development strategies.
Partner with Allumiqs for HCP Analysis
Our expert team combines deep knowledge of LC-MS methodologies with cutting-edge instrumentation to help you:
- Reduce the risk of adverse regulatory outcomes.
- Optimize purification protocols to enhance drug stability and safety.
- Save valuable time and resources during biologics development.
Interested in Enhancing Your HCP Detection Strategy?
Get in touch with our experts
Related Capabilities
Proteomics
Get quantitative data for up to 6500 proteins in your samples with our label-free quantitative proteomics workflow.
Lipidomics
Get in-depth profiling of many classes of biologically relevant lipids using our high resolution instruments.
Metabolomics
Sample profiling using either untargeted metabolomics or selected panels of targeted metabolites is the best technique.
Data Analytics
We help customers unlock the value and potential of their data with clearer, deeper insights.