{"id":5318,"date":"2023-10-06T15:27:10","date_gmt":"2023-10-06T18:27:10","guid":{"rendered":"https:\/\/allumiqs.com\/?page_id=5318"},"modified":"2023-10-10T10:26:42","modified_gmt":"2023-10-10T13:26:42","slug":"drug-target-id","status":"publish","type":"page","link":"https:\/\/allumiqs.com\/drug-target-id\/","title":{"rendered":"Drug Target ID"},"content":{"rendered":"\n
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Drug Target Identification<\/h1>\n\n\n\n

Modify, crosslink, and identify.<\/h2>\n\n\n\n

Do you have a drug that induces the desired phenotype but with an unknown molecular target? Use the combined power of medicinal chemistry and mass spectrometry to discover the target of your drug of interest.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Allumiqs Capabilities<\/h3>\n\n\n\n

Purposed-designed solutions for drug discovery<\/h2>\n\n\n\n

Drug target identification is the first and foremost step in the process of drug discovery. This step could be very laborious due to the complexity of molecular interactions.  <\/p>\n\n\n\n

However, using a clever combination of medicinal chemistry, well-designed protocols, and mass spectrometry, can greatly enhance your chances of success. <\/p>\n\n\n\n

Our team can assist your medicinal chemistry experts by providing insights on the drug design. Once you can provide the modified drug, including the required reactive groups, our team will assist in the design of an experiment based on your research goals and hypothesis.  <\/p>\n\n\n\n

The following is the step-by-step experimental workflow to assist you in your drug discovery journey: <\/p>\n\n\n\n

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  1. Incubate the drug and crosslink; <\/li>\n\n\n\n
  2. Purify the drug\/target complex from the protein solution;  <\/li>\n\n\n\n
  3. Analyze the complex using LC-MS\/MS and identify the target <\/li>\n<\/ol>\n\n\n\n

    As a side note, using a quantitative proteomics workflow enables us to get clearer insights into the real target of the drug, as it is compatible with dose-response experiments. This is why we design the protocols in accordance with our label-free quantitative proteomics workflow. <\/p>\n\n\n\n

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    Get in touch with our team<\/a><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n
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    Related Capabilities<\/h2>\n\n\n\n
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    Proteomics<\/h3>\n\n\n\n

    Optimized and proven mass spectrometry workflows to analyze, characterize, or identify proteins.<\/p>\n\n\n\n

    Learn more<\/a><\/p>\n<\/div>\n\n\n\n

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    Metabolomics<\/h3>\n\n\n\n

    Explore small molecules, and profile your samples for known and unknown metabolites.<\/p>\n\n\n\n

    Learn more<\/a><\/p>\n<\/div>\n\n\n\n

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    Lipidomics<\/h3>\n\n\n\n

    Get in-depth profiling of many classes of biologically relevant lipids using our high resolution instruments.<\/p>\n\n\n\n

    Learn more<\/a><\/p>\n<\/div>\n\n\n\n

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    Data Analytics<\/h3>\n\n\n\n

    We help customers unlock the value and potential of their data with clearer, deeper insights.<\/p>\n\n\n\n

    Learn more<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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    Let’s connect<\/h5>\n\n\n\n

    Get in touch with our experts<\/h2>\n\n\n\n